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KMID : 0350519950480010257
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Journal of Catholic Medical College
1995 Volume.48 No. 1 p.257 ~ p.265
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Relationship of Immunohistochemical Detection of p53 Protein and Clinicopathological Characteristics in Laryngeal Cancer
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Abstract
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Mutation in the p53 gene is turning out to be the most common genetic alteration in various human cancers. P53 tumor suppressor gene acts as a controller in cell cycle and division participating in a G1 check-point control of DNA damage and the
controlling action might be blocked by some viral oncoprotein such as E6 protein of HPV.
We have investigated the p53 protein by immunohistochemical stain and HPV DNA by in situ hybridization in paraffin embedded tissue sections to evaluate the relationship between p53 expression and HPV infection to the various clinical parameters.
Thirty two cases of laryngeal squamous cell carcinoma who underwent laryngectomy from March, 1988 to February, 1992 in Kangnam St.Mary's Hospital of Catholic University Medical College, were subimitted to this study.
@ES The results were as follows ;
@EN 1. P53 protein was detected in 5 cases among the 32 patients (15.6%).
2. There was no relationship between the detection of p53 protein and the clinicopathological parameters.
3. HPV was detected in one case among the 32 patients (3.1%) by in situ hybridization.
4. There was no relationship between the detection of p53 protein and HPV infection.
Above results suggest that the mutation of p53 has no relationship to the clinicopathologic parameters in laryngeal carcinoma and the expression of p53 was not associated with HPV infection.
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